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For instance, administration of FMT from ESKD patients to renal injured germ-free mice or antibiotic-treated rats resulted in an increased production of serum uraemic toxins, exacerbated renal fibrosis and oxidative stress, while control models with FMTs from healthy donors did not show these effects (Wang et al., 2020)

Accordingly, the conclusions of this review emphasize mechanistic plausibility, biological coherence, and translational readiness, rather than claims of established clinical efficacy

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