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It is very important to ensure that the modifications do not reduce the specific binding affinity of the ligands

The D-Nle-X-Ile-NH-(CH 2 ) s -CONH 2 analogs and H-Hinge (13.3xl O "12 M) were incubated with 1 ,25ng of HGF for 40 min at 37C in 0.25 ml of buffer

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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Gojkovic S., Krezic I., Vrdoljak B., Malekinusic D., Barisic I., Petrovic A., Horvat Pavlov K., Kolovrat M., Duzel A., Knezevic M., et al

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As with any research compound, all investigations should be conducted according to appropriate laboratory standards and established scientific procedures
