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As well as this aromatic residue, many of the surrounding residues are also conserved, including charged residues that form key interactions (Fig
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Namely, an increase in heme oxygenase 1 (HO-1) activity in breast cancer cells leads to a transient release of free iron and a consequent increase in ROS content, promoting the expression of matrix metalloproteinase 1 and cell migration [76]

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