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Additionally, the depletion of MnSOD (superoxide dismutase) in RPE cells triggered the Hsp70-linked ubiquitin-dependent cleavage of GPX4, exacerbating ferroptosis of these cells (89)

Resveratrol improves synaptic plasticity in hypoxic-ischemic brain injury in neonatal mice via alleviating SIRT1/NF-kappaB signaling-mediated neuroinflammation

The specific metabolic benefit appears to result from gut bacteria modifications, increased Bifidobacterium and decreased Firmicutes species

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