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Indeed, a review of the preclinical evidence for MET inhibitors in pancreatic cancer acknowledged that none of the preclinical cancer models had considered the role of the stroma in MET/HGF pathway signalling [91]

Chak Kwong Cheng, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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It remains to be understood the exact mechanisms by which adipocyte-generated ceramides promote lipotoxicity

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