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The expression of these genes is directly or indirectly regulated by Nrf-1 and Nrf-2 and coactivators such as peroxisome proliferator-activated receptor coactivator-1 (PGC-1) (227)

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Studies in human fibroblasts revealed activation of phosphatidylinositol 3-kinase (PI3K) via a liganded TR resulting in downstream phosphorylation and activation of PKB/Akt, mTOR and p70 S6K (34)

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