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developmental code PNB-0408) is a synthetic small oligopeptide derived from angiotensin IV (AngIV), engineered to overcome AngIVs limitations as a research tool by adding lipophilic modifications that confer oral bioavailability and blood-brain barrier permeability

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In the system of Ad-P450 cells, it inhibits five P450 enzymes in a concentration-dependent manner (Sasaki et al., 2017)

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When comparing COVID infected patients with or without symptoms of depression and anxiety, imaging tests via MRI showed atrophy of the brain areas responsible for processing emotions and memory