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The 4-HNE is the breakdown product of the decomposition of polyunsaturated fatty acid peroxides that can be used as the biomarkers of lipid peroxidation and to detect oxidative stress damage (Hashimoto et al., 2003)

et al., 2021), Saponin Formosanin C ( c /GSH/GPX4 axis

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10.1074/jbc.M111.253344 J

It is interesting to note that the mutation in alanine of the 6 residues involved either in GSH binding or transport, in addition to the loss of GSH basal transport previously observed (Supplementary Fig