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In a culture system of H 2 O 2 -treated R28 cells, SIRT1 and SIRT3 levels were found to be decreased, and the ROS level was elevated

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Activated astrocytes can shift toward different phenotypes: the A1 type, induced via NF-B signaling, produces proinflammatory mediators and can trigger neuronal apoptosis, whereas the A2 phenotype, driven by STAT3 activation, promotes anti-inflammatory and neuroprotective responses [32]

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10.1080/01480545.2018.1530261 40 KojiT.KikukoA