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In the fatty acid pathway, the accumulation of LCACs is thought to be a major factor in ROS production

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11 Although low concentrations of PPA may be beneficial, humans with impairments in PPA metabolism (that is, propionic or methymalonic acidemia, holocarboxylase, biotinidase or B12 deficiency, valproate or ethanol exposure) exhibit neurodevelopmental conditions with behavioral and biochemical similarities to ASD

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Journal of Medical Biochemistry 34, Pages 151159, ISSN (Online) (2015)

doi: 10.1038/sj.mp.4000805CrossRefGoogle ScholarPubMed Pompili, M., Serafini, G., Innamorati, M., Venturini, P., Fusar-Poli, P., Sher, L., Girardi, P