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However, ACSL4 is not necessary for all ferroptotic cell death, which means under special circumstances ferroptosis is able to be induced in ACSL4-depleted cells ( Ferroptosis is induced due to lipid peroxidation activated via non-enzyme-dependent (Fenton reaction) and enzyme-dependent processes

A pyridazine derivative LDN-212320, which appears to potentiate EAAT2 translation, demonstrated beneficial effects in SOD G93A mice 443 and improved cognitive performance in the APP Sw,Ind AD mouse model 444