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Engagement between academic researchers, industry stakeholders, and regulatory agencies to establish clear pathways for nanomedicine approval, including specific guidance for nose-to-brain products, will be essential

doi: 10.1371/journal.pone.0025298 94 EdwardsJ

2015;10:e0131424

Its cellular uptake is mediated by the highly specific organic cation transporter OCTN1 (encoded by the SLC22A4 gene), which facilitates accumulation of EGT within mammalian cells even against a concentration gradient

Cell immunofluorescence staining For cell immunofluorescence microscopy, cells were seeded on 12 mm coverslips and washing by ice-cold (PBS, pH = 7.4)