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Therefore, UBB+1 is involved in both secretase-dependent and independent pathways for A generation and this could be a reasonable explanation as to why UBB+ conjugated protein aggregation has been found to be associated with A plaques in transgenic UBB+1 AD brain (van Leeuwen et al., 2006

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Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations

In the case of acute lymphoblastic leukemia, targeting glutaminolysis has been demonstrated through the administration of lasparaginase, which reduces plasma glutamine concentration by converting glutamine to glutamate [342]

Furthermore, in this context, different concentrations of nanoSe in conjunction with environmental temperature may influence the growth performance, serum metabolites and gene expression of heatstressed growing quails (Naz, Bibi et al
