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Combining RNA interference with hyaluronan-coated nanoparticles offers a promising strategy for treating glaucoma ( 2.1.7 Adenosine Adenosine is a ubiquitous local modulator that interacts with four membrane receptors: A1, A2A, A2B, and A3 to regulate various physiological and pathological processes ( Activation of A1 receptors in the ciliary body and TM reduces AH production and outflow resistance, lowering IOP ( Adenosine receptor signaling pathways involve molecular mechanisms such as adenylyl cyclase, phospholipase-inositol triphosphate-diacylglycerol, and phosphatidylinositol-3-kinase, which activate MAPK pathways that influence gene transcription ( Several clinical studies, including Phase 2 and 3 trials, have focused on evaluating the efficacy of various topical formulations in lowering IOP in adults with OHT or POAG, comparing them to existing therapies like latanoprost and timolol (NCT01917383, NCT02565173)

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