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Conclusions In vitro and in vivo studies as well as clinical trials in humans show that SIRT-activating compounds derived from natural sources could preserve human health and might prove beneficial for the prevention and treatment of a plethora of human diseases

M., Choi, I.-Y., Cudalbu, C., Dydak, U., Emir, U

This dual dysfunction of microglia and astrocytes leads to extensive oxidative stress, immune activation, and eventual neuronal degradation

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