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Furthermore, recent studies have shown that SCFAs, in addition to their HDAC inhibition effects, can induce propionylation modifications at histone H3K18 and H4K12 sites, inhibit the Wnt/-catenin signaling pathway, upregulate key CRC oncogenes (such as MYC, FOS, and JUN), and downregulate genes related to cell proliferation (ANP32B) and the cell cycle (MKI67), leading to CRC cell death (163)

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doi: 10.1016/j.pneurobio.2005.04.003

Hepatology 64 , 1922 (2016)

From the datamining sources through network biology conducted by Cytoscape, it was found that ACADM, CROT, CRAT, and ACADS are the most prominent genes involved in the function of LC and in the pathology of kidney disease
