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The process of pyroptosis mainly involves the caspase-1-dependent pathway (classical pathway) and the caspase-1-independent pathway (non-classical pathway), and is closely related to the secretion and activation of the pro-inflammatory cytokines interleukin-1 (IL-1) and IL-18, which play an important role in inflammatory response and immune defense through the release of inflammatory mediators and the recruitment of immune cells (103105)

Additionally, FPIinduced epileptic rats displayed behavioral changes, such as pauses, facial automatisms, and myoclonus, during epileptiform events, thereby validating the utility of the FPI model as a valuable tool for studying the underlying mechanisms of spontaneous epileptogenesis [234]

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Since numerous molecules share these signaling pathways, the identification of key molecules is crucial to achieve favorable consequences in cancer therapy