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In the course of this astrogliosis in glaucoma, there is also increased expression of the phagocytosis-related Mac-2 gene and ET-1 by astrocytes, demonstrating both their role in phagocytosis of damaged or dead RGC debris and their involvement in glaucoma-associated vascular dysregulation (Nickells et al., 2012

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(FLVCR is discussed in Sections 3.7 and 3.8.) Increased heme synthesis dampens the activity of the electron transport chain, which ensures an adequate heme supply

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