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Kleme JJ, Fan YV, Jiang P

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The demonstrated importance of protecting the terminals to pharmacokinetic characteristics suggests numerous additional synthetic approaches that may be applicable including the insertion of non-peptide linkages between the first and second amino acids, the replacement of the N~terminal amino acid with a non-a amino acid, and N-terminal acylation

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A study performed in mice supplemented nutritionally with 400 mg/kg/day of synthetic NR showed an increase in NAD + levels in muscle and liver tissue (Cant et al., 2012)