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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Brosnan J.T., Brosnan M.E

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Co-expression of Akt/c-Met stimulates the activation of the MAPK pathway as a result of the synergistic activity [125]

The idea that -Arr signaling via ERK is G protein-independent has been challenged by more recent studies for many receptors including the 2 -AR (OHayre et al., 2017

World J Gastroenterol 24(48):54625476 Lojo N, Rasic Z, Zenko Sever A, Kolenc D, Vukusic D, Drmic D et al (2016) Effects of diclofenac, L-NAME, L-arginine, and pentadecapeptide BPC 157 on gastrointestinal, liver, and brain lesions, failed anastomosis, and intestinal adaptation deterioration in 24 hour-short-bowel rats

There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury