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They should be administered by trained clinicians who screen properly first

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In this vector, referred to as LentiGlobin vector HPV569, the -globin gene is under the control of the LCR and the -globin promoter, and is surrounded by tandem copies of the cHS4 core element [148]

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FDA and the PCAC do review clinical input from practitioners, and well-documented comments describing clinical outcomes, patient need, or safety observations can meaningfully inform the Committees recommendations

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