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There have been reports of corneal clouding or edema following ocular surgery in which BSS PLUS solution was used as irrigating solution
2011;69:34R40R
A third study used metabolomic analysis of lipids to show that the lipid composition of red blood cells may be a good mirror of fatty acids in the retina and the optic nerve, a finding that promises to allow the creation of an index of ocular disease risk 26

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Notably, these specific genes epigenetically modified by DNA hypermethylation regulate cancer response to systemic chemotherapy, making them potential predictive markers for therapy response, as shown in Figure 2