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Implications for cognitive health during aging and the treatment of Alzheimers disease

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[DOI] [PubMed] [Google Scholar] 66.Gruppen EG, Garcia E, Connelly MA, Jeyarajah EJ, Otvos JD, Bakker SJL, Dullaart RPF

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Immunohistochemical staining and Western blot analysis of mouse cochleae showed decreased expression of phosphorylated p38 mitogen-activated protein kinase (MAPK) and phosphorylated c-Jun N-terminal kinase (JNK) [75]

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Exercise activates AMPK pathways that upregulate the same fat oxidation genes (CPT1, ACOX1) targeted by 5-Amino-1MQ-driven sirtuin activation

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In previous years, ferroptosis has been shown to serve a key role in numerous pathological processes, including neurodegenerative diseases, cancer and inflammation-related disorders (3)

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