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In addition to histones, lactate also induces lactylation of snail, a transforming growth factor (TGF)- transcription factor that activates the TGF-/Smad2 signaling pathway, further promoting the EndMT [56]
How does glutathione help mitochondria

Energy expenditure is composed of resting metabolic rate, physical activity, and adaptive thermogenesis including cold-induced and diet-induced thermogenesis
Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells

AAPS J 13:357364 Hadjeri M, Barbier M, Ronot X, Mariotte AM, Boumendjel A, Boutonnat J (2003) Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues

158 METTL3 precisely controls LDHA expression in colorectal cancer through dual mechanisms: stabilizing hypoxia inducible factor 1 subunit alpha (HIF-1) mRNA to increase transcription and promote translation via the m 6 A-YTHDF1 axis
