glutathione peroxidase amino acid sequence Research progress of family (GPX) in redoxidation Glutathione Peroxidase 2 - an

Therapy of mucormycosis

Eligible subjects came to the Georgetown Howard Universities Clinical and Translational Science Clinical Research Unit where diagnosis and study inclusion were confirmed by history and physical examination and subjects provided in person written informed consent

Journal of Natural Products

Zielonka et al., 2015

Monoharpur, Mandawa, Marigaon, Pallikonda, Pindwara, Shishgarh, Patur, Mayang Imphal, Mhowgaon, Guruvayoor, Mhaswad, Sahawar, Sivagiri, Mundargi, Punjaipugalur, Kailasahar, Samthar, Sakti, Sadalagi, Silao, Mandalgarh, Loha, Pukhrayan, Padmanabhapuram

Key Points Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic cells An accumulating body of evidence suggests that T1DM is associated with loss of tolerance by autoreactive B cells Although islet antigen-reactive B cells give rise to autoantibody secreting cells, their most important contribution to pathology in T1DM seems to be presentation of self-antigens to T cells Loss of tolerance of islet-reactive B cells is associated with certain genetic polymorphisms B cells contribute to diabetic kidney disease (DKD) through the production of antibodies that lead to the formation and deposition of immune complexes in the kidney In a clinical trial, B cell-depletion therapy showed some efficacy in patients with T1DM