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Garland et al., 2023)

Many cancers, particularly glioblastomas, are associated with increased activity of the malate-aspartate shuttle as a consequence of increased expression of the MDH2 gene

Ischemia-reperfusion (I/R) injury leads to decreased endothelial barrier function, increased permeability, and cellular edema, resulting in microthrombi, microvascular occlusion, and reduced blood supply, exacerbating reperfusion injury (Gao et al., 2019

However, this notion has been widely contested

In The Textbook of Spinal Surgery, 2nd Edition, Bridwell, K.H., DeWald, R.L

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