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Blakemore, A

Low-Moderate = robust animal data, no human RCTs

Uncontrolled innate and impaired adaptive immune responses in patients with COVID-19 acute respiratory distress syndrome

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This imbalance can result from increased free radical production, decreased antioxidant defenses, or both [7]

This is possible only in the presence of a right-left shunt at the level of an open oval window (paradoxical embolism), as well as an embolism substrate (in adult patients, these are blood clots in the varicose veins of the lower extremities).Given the lack of indications for surgical closure of a functioning oval window, the latter is currently not indicated