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Similar results were obtained in cultured B16F10 melanoma cells where AC reduced levels of tyrosinase, tyrosinase-related protein-1 (TRP-1), and microphthalmia-associated transcription factor (MITF) proteins by activating extracellular signal-regulated kinase (ERK) signaling (Son et al

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Similarly, in colon adenocarcinoma, increased MnSOD expression in adjacent normal tissuesbut not within tumors themselvescorrelates with poor prognosis, further supporting its role as a nuanced prognostic indicator [122]