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B.LastraM.Rodrguez-ArgellesM

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The most adverse effects were observed in the kidney due to a significant increase in the inflammatory biomarkers MCP-1 and IL-6 at a dose of 100 mg/kg bw/day and TNF-, resistin and PAI-1 were significantly increased at a dose of 100 mg/kg bw/day, 100 mg/kg bw/day, and 200 mg/kg bw/day, respectively (Figure 5)

Loguercio, C., D'Argenio, G., Delle Cave, M., Cosenza, V., Della Valle, N., Mazzacca, G., & Del Vecchio Blanco, C

it reflects a growing recognition of the central role of metabolic dysfunction in the pathogenesis of steatotic liver disease and aligns diagnostic criteria with our expanding understanding of its underlying mechanisms