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In severe cases, it can lead to rickets in children and osteomalacia (softening of bones) in adults
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For more details on how size exclusion chromatography works, see this article

Herein, we successfully switched a patient with acromegaly from a dipeptidyl peptidase-4 (DPP-4) inhibitor to a glucagon-like peptide-1 (GLP-1) analog due to pasireotide-induced deterioration of glycemic control, and we examined the underlying mechanism for glycemic control

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