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It has also been suggested that the combination of folate, vitamin B12, and vitamin B6 may improve methylation, increase transsulfuration, and possibly reduce stress

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However, while specific populations (such as subjects with documented zinc deficiency or at risk of severe malnutrition) appear to greatly benefit from zinc supplementation in terms of thyroid function, the role of zinc supplementation in the general population as a protective factor for thyroid disorders is still not fully established [62]