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In AD-GTPCHD patients, disease onset is typically during the first decade of life (mainly between 3 to 9 years of age), although very rarely patients may present with dystonia and/or developmental delay in the first 1218 months [33, 34]

Sikiric et al., 1993

The neurovascular unit, consisting of endothelial cells, astrocytes, pericytes, neurons, and extracellular matrix components, is also disrupted in CSVD

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