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Flowchart for Implementing Advanced Imaging and Electrophysiology in Patients With Disorders of Consciousness: To fMRI or Not to fMRI

In a state of oxidative stress, the ratio can be as low as 10:1, and in severe states of oxidative stress, as low as 1:1

It is driven by the accumulation of iron-dependent LPOs

This phenomenon is known as induced systemic resistance (ISR) (Pieterse et al., 2014)

10.3389/fphar.2022.750208 21 ChengK.HaoM

62,63 Based on human fetal graft studies, these numbers translate to 40,00080,000 healthy dopaminergic neurons, unidirectional axonal architecture of 35 cm in length, and dopamine release of 7 ng/mg of tissue for nigrostriatal pathway restoration in humans (Table 1)