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Acetaldehyde in the brain causes euphoria at low doses and plays a vital role in ethanols reinforcing properties, thereby facilitating alcohol addiction (Quertemont et al., 2005

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This well-established importance underlies the role of vitamin B12 deficiency in mood imbalances, psychotic disorders, and neuronal health, particularly in elderly patients, where this deficiency is estimated to affect up to 40% of the population (72)

Moreover, accompanied by less efficient production of ATP, damaged mitochondria are more efficient producers of ROS [103], and this oxidative stress could account for the loss of synaptic functions associated with learning and memory in AD [104]