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Description
5-Amino-1MQ steps in as an NNMT inhibitor, effectively dialing down this enzymes activity
NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models
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Trends Endocrinol Metab (2017) 28(5):34053
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