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IL-1 Upregulates IL-8 production in human Mller cells through activation of the p38 MAPK and ERK1/2 signaling pathways

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In vivo , they found that NNMT knockdown mice had higher energy expenditures than the control mice with similar body weights [11]

Hu [20] found that many colon cancer (CRC) cell lines were resistant to ferroptosis induced by the traditional ferroptosis inducers erastin and RSL3

Additionally, research has illuminated potential mechanisms involved in TGF-1-induced ASM remodeling, encompassing pathways such as the phosphorylation of p38 and ERK1/2 (284), the up-regulation of miR-181a and miR-328-3p through the suppression of phosphatase and tensin homolog (PTEN) protein and increased p-Akt/Akt ratio suggesting TGF-1 induced ASM remodeling involves PTEN and Akt signaling pathway (285, 286), and the modulation of intracellular calcium levels [(Ca2+)i] and/or activation of Rho-associated protein kinase (ROCK) (287)

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Medin T., Medin H., Hefte M.B., Storm-Mathisen J., Bergersen L.H