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In degenerative chondrocytes, elevated IL-6 expression triggers lipid peroxidation and iron imbalance via the IL-6/miR-10a-5p/IL-6R axis, thereby promoting ferroptosis and exacerbating inflammation associated with intervertebral disc degeneration (Jeong et al., 2003)

To further explore this effect, we examined additional GGT inhibitors (acivicin and OU749) 45 but found that GGsTop was the most potent at blocking GGT activity (Fig

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ADR The incidence of ADR in the safety evaluation analysis group was 8.08% (8/99 patients), whereas chest discomfort was reported in 4.04% (4/99) of the patients

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These characteristics make SAMP8 mice particularly suitable for investigating sporadic AD and its progression (Table 6)