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Preclinical animal studies further validate its neuroprotective potential: phillyrin A improves learning and memory in senescence-accelerated mice, activates the Nrf2 signaling pathway in APP/PS1 mice, upregulates antioxidant proteins (NQO1, GPX4), and normalizes cerebral iron content through modulation of TFRC, DMT1, FTH, and FTL gene expression (234)
[PubMed] [Google Scholar] [26].Laitinen LA, Lindqvist A, Heino M
The synthesis and degradation of GSH play an important part in GSH abundance
Moreover, we identified a MYC-degrading molecule, A80.2HCl, that efficiently reduces MYC protein levels and overcomes CDK4/6i resistance (Fig
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