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161,162,163,164,165 One of these, olaratumab, was tested clinically and was received accelerated approval by the FDA for the treatment of advanced soft tissue sarcoma based on a successful phase II result, but unfortunately did not show similar benefit in a subsequent phase III trial

The metabolic basis of kidney cancer

Hypoxia induces metabolic reprogramming in ECs, characterized by enhanced glycolysis and pentose phosphate pathway (PPP) activity alongside reduced tricarboxylic acid (TCA) cycle flux and mitochondrial respiration

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Despite these points, for studies where efficacy and precise control are paramount, the benefits often outweigh the logistical hurdles

Molecular characterization of CNAs improves the selection of treatment strategies, emphasizing the need for integrating CNA data into clinical trial designs to ensure more representative patient cohorts