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Epitalon and the bigger picture Epitalon, a tetrapeptide (Ala-Glu-Asp-Gly), does not function as a direct antidepressant

Similar findings were obtained in the study of Vinderola et al
Biochemistry 2020, 59 (19), 18131822

Preventing normal FOXO4 binding to p53 through FOXO4-DRI has been suggested to remove senescent cells, improve organ function, and slow biological age. The cell cycle, oxidative stress, and the insulin signaling pathways may all be affected by FOXO4-DRI, as speculated by researchers
619 Oxidative enzymes (e.g., CYP) are rapidly upregulated in immune cells in human dental pulpitis and in trigeminal nociceptive afferent neurons after orofacial inflammation, resulting in a great capacity to generate lipid mediators able to activate the pain circuits
