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Vitamin Supplementation Reduces Blood Homocysteine Levels: A Controlled Trial in Patients with Venous Thrombosis and Healthy Volunteers. Arteriosclerosis, Thrombosis, and Vascular Biology, vol

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The oxidation of SeMet to SeMetO is not limited to ONOOH, and an analogous reactivity has also been observed for other oxidants, such as H 2 O 2 , the enzymatic monooxygenase system, amino acid-, peptide- and protein-bound hydroperoxides, hypothiocyanous acid HOSCN and hypochlorite HOCl-derived chloramines [40,41,42]

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GPX-like proteins have been reported in many species, the importance of Sec has been recognized, and Sec-based glutathione peroxidase has been extensively studied in mammals, but they appear to play different roles in different locations or cells (Handy et al., 2021)