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This approval marked the first oral GLP-1 RA indicated specifically for obesity, creating a new option for patients and clinicians who prefer or require non-injectable therapies, in contrast to Rybelsus, an oral semaglutide approved for the treatment of type 2 diabetes

Translationally, the apelinAPJ system illustrates a broader challenge for metabolic peptides with cardiovascular overlap: indication-specific development is likely required

[DOI] [PubMed] [Google Scholar] 236.Orskov C., Wettergren A., Holst J.J

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Luconi M, Mangoni M, Gelmini S, Poli G, Nesi G, Francalanci M, et al

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