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A 2022 systematic review found mixed outcomes: some gastroparesis patients tolerated low-dose GLP-1 therapy without symptom exacerbation, while others experienced significant worsening

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60 Similarly, another controlled, randomized trial by Drucker et al 61 compared exenatide once weekly to exenatide twice daily treatments and found that injection-site pruritus was experienced by 17.6 percent of patients on the once weekly regimen and by 1.4 percent of patients on the twice daily regimen

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