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Network-based drug repurposing has leveraged betweenness and closeness centrality to rank pathway significance and predict drug-disease associations 33,34 , while centrality metrics have also been used to examine disease co-occurrence and mechanistic overlaps 19,35

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The proper technique involves holding the vial between your thumb and fingers and making slow, gentle circular motions that cause the liquid to swirl around the inside of the vial without creating foam or turbulence

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