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A year later, those on the medication lost about 8 percent of their weight

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Compensatory changes in the levels of weight-regulating hormones such as leptin, ghrelin, peptide YY, and gastric inhibitory peptide can counteract diet-induced weight loss, highlighting the difficulty in maintaining weight loss through diet alone [11]

And while he'd like to see the "root cause" of obesity and related chronic diseases tackled, he says he's "not optimistic that we're going to change the food environment overnight

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