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Stability studies were conducted at 25C, 40C, and 55C for 24h in water, with extended studies at 5C, 25C, 40C, 60C, and 80C

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The greater weight loss seen with tirzepatide may be due to the additional activation of the GIP receptor, which appears to further enhance insulin sensitivity, reduce food intake, and promote fat breakdown

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After a maximum 12-week screening phase, an anticipated 1840 patients in each trial are randomized (1:1) to semaglutide or placebo for 156 weeks (104-week main treatment phase and 52-week extension)