glp-1/gip receptor agonists GLP-1 – Peripheral Brain Possible mechanisms of the interaction

Exercise has been shown to synergize with ketogenic diets and intermittent fasting by further improving insulin sensitivity, promoting fat loss, and preserving lean muscle mass

HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]

Conclusions In this cohort study, the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a lower risk of major adverse cardiovascular events and serious renal events compared with either drug class alone

It can involve insulin resistance, higher androgen levels, acne, facial hair growth, irregular ovulation, weight gain, inflammation, cholesterol changes, blood sugar problems, fatty liver risk, and increased cardiovascular risk

New avenues in the regulation of gallbladder motility-implications for the use of glucagon-like peptide-derived drugs

10.1016/j.brainres.2005.03.011 3 AgersoH.JensenL