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SHP2 is thought to also play a role during embryonic development by preventing the formation of AChR clusters in extra-synaptic sites that are not directly in contact with the motor nerve terminal (Qian et al., MuSK AntibodiesDiscovery and Pathogenicity Studies The constant and finely-tuned activation of the agrin-LRP4-MuSK-DOK7 pathway maintains the AChRs in high-density clusters on the post-synaptic membrane that is vital for the correct function of the NMJ

Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1 secretion

Any insoluble material was pelleted by centrifugation (13,000 g , 10 min, 4 C) and then 100 l of supernatant CL was transferred to a clean microcentrifuge tube

A controversial preservative that has formaldehyde-releasing properties

doi: 10.3390/toxins12050297 8 BelitskyB

Autophagy is a cellular process that involves the recycling of materials, and is typically initiated during nutrient deprivation or other stressful conditions to aid in the elimination of damaged proteins and organelles (50)