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Of the 14 semaglutide-treated patients that developed anti-semaglutide antibodies, 7 patients (0.2% of the overall population) developed antibodies cross-reacting with native GLP-1

Reddit users skew younger and are disproportionately based in the U.S., so the sample does not represent the global population of drug users

Interestingly, SGB appears to be able to improve sleep by reducing inflammation, increasing melatonin levels, and increasing blood flows

However, semaglutide is not designed as an immunomodulatory agent

American College of Gastroenterology EvidenceBased Guidelines , 2024

However, semaglutide at the higher Wegovy dose generally produces stronger results in both HbA1c reduction and weight loss