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While the primary mechanisms of CPZ toxicity are poorly understood, in vitro studies report CPZ toxicity to be limited to primary oligodendrocytes (Bnardais et al., 2013) while others suggest the requirement of pro-inflammatory cytokines (Pasquini et al., 2007)

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10.1051/ebr:2007034 125 HidalgoA.LopategiA.PrietoM.SerraJ

These observations indicate that VGF is required for granule biogenesis and glucagon maturation in cells